Services

Services

IDBR offers the following services to companies and institutions on a fee for service basis

  • Analytical method development
  • Formulation Development
  • Stability studies
  • In-vitro Release Test (IVRT)- Oral and topical dosage forms
  • In vitro Permeability Test- Skin, nail and mucous membranes
  • Physicochemical characterization of APIs and excipients
Animal Studies
  • Skin sensitivity studies
  • Plasma pharmacokinetic studies in animal models
  • CNS pharmacokinetics of drugs
  • Skin pharmacokinetics of drugs
  • Nail pharmacokinetics of drugs
  • Pharmacodynamic studies in animal models
    • Anti-diabetic activity
    • Treatment of Hypetrophic Scars
    • Treatment of acute and chronic wounds
    • Skin hydration
    • Anti inflammatory activity
    • Collagen production/denaturation assays
    • Antioxidant property
  • Bioavailability/Bioequivalence in animal models
Cell culture
  • Cell viability assays
  • Anticancerous activities
  • ELISA
Human subject studies
  • Pharmacokinetic studies
  • Dermal kinetics of drugs (DPK studies)
  • Tape stripping studies
  • Evaluation of sensory characteristics of products
  • Palatability of dosage forms

DMPK Services

Physicochemical properties
  • Solubility (Thermodynamic and Kinetic method) In buffers of Various pH (PBS, FASSIF, FESSIF, FESGF, FASGF or any assay buffers)
  • Simultaneous determination of Log P, Log D and pKa
  • Chemical Stability
  • Blood Partitioning
Animal Pharmacokinetics
  • Pharmacokinetics by various routes viz., oral, intravenous, intra-peritoneal, subcutaneous in mice and rats.
  • Tissue Distribution
  • Mass Balance
In vitro Permeability
  • PAMPA
  • MDR1-MDCK
  • Caco-2
Protein Binding
  • Plasma Protein Binding (ultra Filtration and Equilibrium Dialysis)
  • Microsomal Protein Binding
In vitro Metabolism
  • Metabolic Stability , Liver Microsomes , S-9 Fraction , Cryopreserved Hepatocyte .
  • Cytochrome P450 Inhibition
  • Plasma Stability